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S-binding IgG

Biomarker

1 paper studies it3 findings

  • Humans1

Interventions

1

COVID-19 mRNA vaccine

upin humans1

1 study

  1. COVID-19 mRNA vaccine increases S-binding IgG in humans (99-fold).

    “The 3rd mRNA dose elicited a 99-fold relative increase of S-binding IgG in blood and corresponding increase of neutralizing antibodies.”

    Humansmonovalent3rd dose

    Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study

    The Lancet regional health. Europe

More on COVID-19 mRNA vaccine

Effects

1

COVID-19

no changein humans1

1 study

  1. S-binding IgG has no effect on COVID-19 in humans.

    “We found no indication that levels of vaccine-induced antibodies protected against infection with Omicron VOCs.”

    HumansOmicron VOCs

    Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study

    The Lancet regional health. Europe

More on COVID-19

Associations

1

Mortality

downin humans1

1 study

  1. S-binding IgG lowers the risk of mortality in humans.

    “In contrast, the risk of death was inversely correlated to levels of S-directed IgG below the 20th percentile.”

    Humansbelow the 20th percentile

    Vaccine-induced correlate of protection against fatal COVID-19 in older and frail adults during waves of neutralization-resistant variants of concern: an observational study

    The Lancet regional health. Europe

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