What does the research say about reticular pseudodrusen load?

Reticular pseudodrusen load

There is 1 paper on reticular pseudodrusen load in aging research: 1 observational study in people. The newest story, Nov 9, 2026: “Certain eye deposits linked to higher stroke odds in older adults”.

Biomarker

1 paper studies it2 findings

See all 1 papers on reticular pseudodrusen load

“Multivariable analysis showed a significant association between RPD load and stroke risk (OR 1.02, 95% CI 1.00 to 1.04, p=0.042) after adjustment for confounders.”

Reticular pseudodrusen load is associated with an increased risk of strokeBMJ open ophthalmology2026doi:10.1136/bmjophth-2025-002481

Humans1

Effects

Myocardial infarction

no changein humans1

1 study

Reticular pseudodrusen load was not clearly linked with myocardial infarction in humans.
“No significant association was found between drusen and stroke or between RPD/drusen and MI.”
Humansn = 2,010
Certain eye deposits linked to higher stroke odds in older adults
BMJ open ophthalmologyJul 20, 2026

Associations

Stroke

upin humans1OR 1.02

1 study

Reticular pseudodrusen load is linked with a higher risk of stroke in humans (multivariable analysis adjusting for confounders) (OR 1.02, 95% CI 1.00 to 1.04, p=0.042 per 20 RPD lesions).
“Multivariable analysis showed a significant association between RPD load and stroke risk (OR 1.02, 95% CI 1.00 to 1.04, p=0.042) after adjustment for confounders.”
Humansmultivariable analysis adjusting for confoundersn = 2,010
Certain eye deposits linked to higher stroke odds in older adults
BMJ open ophthalmologyJul 20, 2026

Latest

1 paper in 12 months

BMJ Open OphthalmologyJul 21

Certain eye deposits linked to higher stroke odds in older adults

Each additional 20 deposits was linked to 1.02 times the odds of stroke; the association weakened after accounting for smoking.Each additional 20 deposits was linked to 1.02 times the odds of stroke; the association weakened after accounting for smoking.

Cross-sectional · 2,010 peopleStroke

Paper