Proteomic brain age
Biomarker1 paper3 findings
- Humans1
Effects
1Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
Proteomic brain age impairs cognitive function in humans.
“accelerated brain aging was associated with lower cognitive scores.”
Humansaccelerated brain agingplasman = 53,005
Plasma‐based Brain Age as a Biomarker for Cognitive Health and Risk of Brain‐Related Diseases · AAIC 2025 abstract · 24 Dec 2025
Associations
2Stroke
upin humans1HR 1.3
1 study
Stroke
upin humans1HR 1.3
Proteomic brain age raises the risk of stroke in humans (HR 1.30 (95% CI 1.22-1.38)).
“accelerated brain aging was associated with an increased risk of AD (HR, 95% CI: 1.88 (1.74‐2.03)) and stroke (HR, 95% CI: 1.30 (1.22‐1.38)).”
Humansaccelerated brain agingplasman = 53,005
Plasma‐based Brain Age as a Biomarker for Cognitive Health and Risk of Brain‐Related Diseases · AAIC 2025 abstract · 24 Dec 2025
Alzheimer's disease
upin humans1HR 1.88
1 study
Alzheimer's disease
upin humans1HR 1.88
Proteomic brain age raises the risk of Alzheimer's disease in humans (HR 1.88 (95% CI 1.74-2.03)).
“accelerated brain aging was associated with an increased risk of AD (HR, 95% CI: 1.88 (1.74‐2.03))”
Humansaccelerated brain agingplasman = 53,005
Plasma‐based Brain Age as a Biomarker for Cognitive Health and Risk of Brain‐Related Diseases · AAIC 2025 abstract · 24 Dec 2025