What does the research say about primary methylation index?

Primary methylation index

There is 1 paper on primary methylation index in aging research: 1 observational study in people. The newest story, Nov 13, 2026: “Arsenic metabolism linked to muscle size and fat in adults”.

Biomarker

1 paper studies it1 finding

1 new paper in 30 daysSee all 1 papers on primary methylation index

“a doubling of PMI, indicating incomplete As metabolism, was associated with lower muscle area (β=-1.95 cm2) and density (β=-1.20 Hounsfield Units).”

Arsenic metabolism is associated with muscle area and adiposity: The Multi-Ethnic Study of Atherosclerosis (MESA)Environmental research2026doi:10.1016/j.envres.2026.126177

Humans1

Associations

Abdominal muscle area

downin humans1

1 study

Primary methylation index is associated with abdominal muscle area in humans (fully adjusted models) (β=-1.95 cm2 per doubling of PMI).
“a doubling of PMI, indicating incomplete As metabolism, was associated with lower muscle area (β=-1.95 cm2) and density (β=-1.20 Hounsfield Units).”
Humansfully adjusted modelsabdominal skeletal muscledoubling of PMI49% femalesn = 1,597
Arsenic metabolism linked to muscle size and fat in adults
Environmental researchNov 1, 2026

Latest

1 paper in 12 months

Environmental ResearchNov 13

Arsenic metabolism linked to muscle size and fat in adults

A 5% increase in the urinary share of one substance formed from arsenic was linked to 1.62 square centimeters less abdominal muscle area.A 5% increase in the urinary share of one substance formed from arsenic was linked to 1.62 square centimeters less abdominal muscle area.

Cross-sectional · 1,597 peopleMuscle

Paper

Primary methylation index

Associations

Latest

Arsenic metabolism linked to muscle size and fat in adults

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