Predicted RNFL thickness change

1. Intraocular pressure is associated with predicted RNFL thickness change in humans (β = -0.020 μm/year per mmHg).

   “higher baseline IOP (β = -0.020 μm/year per mmHg; P < 0.001)”

   Humansretina3-year follow-upn = 18,247

   Deep Learning-Predicted RNFL Loss and Incident Glaucoma in the Canadian Longitudinal Study on Aging

   Ophthalmology. Glaucoma·19 Mar 2026

More on Intraocular pressure

1. Older age is associated with predicted RNFL thickness change in humans (β = -0.223 μm/year per decade).

   “faster thinning was associated with older age (β = -0.223 μm/year per decade; P < 0.001)”

   Humansretina3-year follow-upn = 18,247

   Deep Learning-Predicted RNFL Loss and Incident Glaucoma in the Canadian Longitudinal Study on Aging

   Ophthalmology. Glaucoma·19 Mar 2026

1. Predicted RNFL thickness change predicts glaucoma in humans (HR 1.125 (95% CI, 1.070-1.183) per 1 μm/year increase).

   “Faster-predicted RNFL loss was independently associated with incident glaucoma during follow-up (hazard ratio = 1.125 per 1 μm/year increase; 95% confidence interval, 1.070-1.183; P < 0.001).”

   Humansretina3-year follow-upn = 17,552

   Deep Learning-Predicted RNFL Loss and Incident Glaucoma in the Canadian Longitudinal Study on Aging

   Ophthalmology. Glaucoma·19 Mar 2026

More on Glaucoma