What does the research say about positive methylation burden call?

Positive methylation burden call

There is 1 paper on positive methylation burden call in aging research: none in people yet. The newest story, Nov 13, 2026: “Blood DNA screen false positives rose with age”.

Biomarker

1 paper studies it1 finding

1 new paper in 30 daysSee all 1 papers on positive methylation burden call

“Positive calls rose with age: 0.3% (< 60 y), 1.9% (60–69), 2.5% (70–79) and 7.5% (≥ 80; 95% CI 4.3–12.7). Odds ratio per 10 years 2.22 (1.21–4.07).”

Age-specific false positives and the clinical pathway for a whole-blood DNA-methylation burden screen in older adults and carriers of clonal hematopoiesis: an open-data evaluationResearch Square2026doi:10.21203/rs.3.rs-10397076/v2

In silico1

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Age

upin humans1

1 study

Age is associated with positive methylation burden call in humans (Without known myeloid disease) (OR per 10 years 2.22 (1.21–4.07)).
“Positive calls rose with age: 0.3% (< 60 y), 1.9% (60–69), 2.5% (70–79) and 7.5% (≥ 80; 95% CI 4.3–12.7). Odds ratio per 10 years 2.22 (1.21–4.07).”
HumansWithout known myeloid diseasewhole blood
Blood DNA screen false positives rose with age
Research SquareNov 12, 2026Preprint

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Research SquareNov 13

Blood DNA screen false positives rose with age

False-positive rates rose from 0.3% below age 60 to 7.5% at 80 or older in an analysis of whole-blood samples.False-positive rates rose from 0.3% below age 60 to 7.5% at 80 or older in an analysis of whole-blood samples.

Preprint: cross-sectional studyBiomarkers

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Positive methylation burden call

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Blood DNA screen false positives rose with age

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