Polygenic risk score for long-term condition burden

Polygenic risk score for long-term condition burden is associated with long-term condition burden in humans (0.73 more long-term conditions in highest versus lowest 10%).

“Individuals in the highest 10% PRSLTC had, on average, a 0.9-year shorter lifespan and 0.73 more LTCs than those in the lowest 10%.”

HumansHighest versus lowest 10% of PRSLTCn = 34,339

Genetic insights into number of long-term conditions and their relationship with lifespan

PloS one·30 Jan 2026

Polygenic risk score for long-term condition burden is associated with lifespan in humans (0.9-year shorter lifespan in highest versus lowest 10%).

“Individuals in the highest 10% PRSLTC had, on average, a 0.9-year shorter lifespan and 0.73 more LTCs than those in the lowest 10%.”

HumansHighest versus lowest 10% of PRSLTCn = 34,339

Genetic insights into number of long-term conditions and their relationship with lifespan

PloS one·30 Jan 2026