Plasma soluble TREM2

1. TREM2R47HVARIANT is associated with plasma soluble TREM2 in humans (R47H TREM2 carriers compared with non-carriers).

   “Plasma sTREM2 and brain Aβ load were higher in R47H TREM2 carriers compared to non-carriers.”

   HumansR47H TREM2 carriers compared with non-carriers

   Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimer's disease

   Journal of Alzheimer's disease : JAD·Dec 9, 2025

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1. Plasma soluble TREM2 is associated with kynurenine pathway metabolites in humans.

   “Plasma sTREM2 positively correlated with serum microglial kynurenine pathway metabolites.”

   Humans

   Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimer's disease

   Journal of Alzheimer's disease : JAD·Dec 9, 2025

More on Kynurenine pathway metabolites

1. Plasma soluble TREM2 is associated with plasma pTau-181 in humans.

   “Plasma sTREM2 positively correlated with plasma pTau181, and pTau231 in CN Aβ+ group.”

   Humanscognitively normal older adults with brain amyloid-β positivity (CN Aβ+); pTau-231 reported togethern = 35

   Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimer's disease

   Journal of Alzheimer's disease : JAD·Dec 9, 2025

More on Plasma pTau-181