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NLRP3 promoter methylation

Biomarker

1 paper studies it2 findings

See all 1

  • Humans1

Upstream

1

Age

upin humans1

1 study

  1. age increases NLRP3 promoter methylation in humans (p = 0.0038 and p = 0.0018).

    “In IBD adults, methylation levels at both NLRP3 CpG sites increased with patients' age (p = 0.0038 and p = 0.0018, respectively).”

    Humansinflammatory bowel diseasen = 47

    NLRP3 promoter methylation as a predictive biomarker for glucocorticoid response in patients with inflammatory bowel disease

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Associations

1

Poor glucocorticoid response

downin humans1

1 study

  1. NLRP3 promoter methylation is associated with poor glucocorticoid response in humans (p = 0.045 and p = 0.038).

    “poor glucocorticoid response after one month of therapy in pediatric patients was associated with lower methylation levels at both CpG sites (p = 0.045 and p = 0.038, respectively)”

    Humansinflammatory bowel disease1 monthn = 94

    NLRP3 promoter methylation as a predictive biomarker for glucocorticoid response in patients with inflammatory bowel disease

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

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