Communications Biology
Brain cells responded less flexibly in Alzheimer’s model mice
An imaging experiment in behaving mice found higher baseline brain-cell activity but weaker movement-driven responses in a brain region involved in memory.An imaging experiment in behaving mice found higher baseline brain-cell activity but weaker movement-driven responses in a brain region involved in memory.
Mouse studyMechanisms
Who was studiedBehaving 5xFAD mice
What changedBrain-cell activity varied over a narrower range in Alzheimer’s model mice
The catchCalcium imaging served as a proxy for neuronal firing