Multimodal cardiac age gap

Multimodal cardiac age gap predicts mortality in humans (HR 2.24 per unit increase in age gap, 95% CI 1.71–2.92).

“we observed a hazard ratio (HR) of 2.24 (95% confidence interval: 1.71-2.92) per unit increase in the age gap”

HumansAverage age gap across coronary angiography, echocardiography, and ECG; echocardiogram and ECG obtained within one month of angiogramheartn = 1,345

Seeing the Aging Heart: Multimodal AI Quantifies Cardiac Biological Aging from Angiography, Echocardiography, and ECG

medRxiv·28 Oct 2025Preprint