MMP12 EpiScore
Biomarker1 paper3 findings
- Humans1
Associations
3MMP-12
upin humans1
1 study
MMP-12
upin humans1
MMP12 EpiScore is associated with MMP-12 in humans (rho=0.47, p < 0.0001).
“Subsequent proteome‐wide analyses found EpiScore MMP12 (i) accounted for 22% of variation in concurrently measured plasma MMP12 ( n = 186; rho=0.47; p < 0.0001)”
Humansconcurrent plasma measurementplasman = 186
Epigenetic signatures of plasma protein abundance are associated with longitudinal brain and cognitive trajectories in older adults · AAIC 2025 abstract · 25 Dec 2025
SPARE-AD
upin humans1
1 study
SPARE-AD
upin humans1
MMP12 EpiScore is associated with SPARE-AD in humans.
“An elevated MMP12 EpiScore was associated with steeper decline in total brain volume and cognition, as well as increases in SPARE‐AD.”
Humanslongitudinal trajectorybrainup to 16.4 yearsn = 431
Epigenetic signatures of plasma protein abundance are associated with longitudinal brain and cognitive trajectories in older adults · AAIC 2025 abstract · 25 Dec 2025
Cognitive function
downin humans1
1 study
Cognitive function
downin humans1
MMP12 EpiScore is associated with cognitive function in humans.
“An elevated MMP12 EpiScore was associated with steeper decline in total brain volume and cognition, as well as increases in SPARE‐AD.”
Humanslongitudinal trajectoryup to 20.2 yearsn = 681
Epigenetic signatures of plasma protein abundance are associated with longitudinal brain and cognitive trajectories in older adults · AAIC 2025 abstract · 25 Dec 2025