BiomarkersHumans681 participants20.2 yearsCohort study

Epigenetic signatures of plasma protein abundance are associated with longitudinal brain and cognitive trajectories in older adults

AAIC 2025 Abstract

Abstract

Background: The biological processes underlying heterogeneous brain and cognitive trajectories in aging have been extensively informed through associations with the plasma proteome; however, circulating protein levels can be highly variable, susceptible to measurement error, and vulnerable to other fluctuations.

The paper

Drouin SM, Kuo P, Blew CO et al.

AAIC 2025 Abstract · 25 Dec 2025 · CC BY

Presented at AAIC 2025

doi.org/10.1002/alz70856_103678