MileAge

1. MileAge is associated with frailty phenotype in humans (OR = 1.29, 95% CI 1.23–1.35).

   “Individuals with a metabolite-predicted age older than their chronological age were also more likely to be physically frail (OR = 1.29, 95% CI 1.23–1.35, P < 0.001).”

   Humansmetabolite-predicted age older than chronological ageplasman = 200,000

   A Metabolite-Wide Association Study Of Frailty In Over 200,000 Adults · GSA 2025 abstract · 31 Dec 2025

Frailty phenotype →

1. MileAge is associated with frailty index in humans (β = 0.023, 95% CI 0.021–0.024).

   “A metabolite-predicted age (MileAge) older than one’s chronological age was associated with higher frailty index scores (β = 0.023, 95% CI 0.021–0.024, P < 0.001”

   Humanscomparing individuals with a MileAge delta at least one standard deviation above and below the meanplasman = 200,000

   A Metabolite-Wide Association Study Of Frailty In Over 200,000 Adults · GSA 2025 abstract · 31 Dec 2025

Frailty index →