Metabolic meta-subtypes

Metabolic meta-subtypes are associated with susceptibility to type 2 diabetes and neurodegenerative disorders in humans (13 metabolic subtypes consolidated into four meta-subtypes).

“four meta-subtypes with markedly divergent susceptibility profiles for major age-related diseases, particularly type 2 diabetes and neurodegenerative disorders.”

HumansDifferences persisted at comparable levels of age acceleration

Decoding heterogeneous aging clocks and disease risk stratification using MetAgeFormer

bioRxiv (Cold Spring Harbor Laboratory)·20 May 2026Preprint