bioRxiv
Measures of aging in cell structures linked to disease risk
Among 61,931 people, four or more prematurely aged compartments were linked to up to 22-fold higher kidney disease risk and up to 8-fold higher mortality risk.Among 61,931 people, four or more prematurely aged compartments were linked to up to 22-fold higher kidney disease risk and up to 8-fold higher mortality risk.
Preprint: cohort study of 61,931 peopleBiomarkers
Who was studied61,931 people across the human lifespan
What changedKidney disease risk was up to 22-fold higher among people with four or more prematurely aged compartments
The catchFluid proteins served as proxies for organelle aging rather than direct measurements inside cells