Lung clearance index

1. Lung clearance index was not clearly linked with FEV1/FVC in humans.

   “No relationships were observed between LCI and FEV1/FVC or RV/TLC”

   Humanslungn = 79

   Contribution of peripheral airway function to changes in FEV₁/FVC and RV/TLC with aging

   Journal of applied physiology (Bethesda, Md. : 1985)·Aug 23, 2018

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1. Lung clearance index is associated with pulmonary obstruction in humans (High LCI).

   “Reduction of FEV1 between 55 and 68 years of age and incidence of pulmonary obstruction was highest in those with high LCI.”

   HumansHigh LCIlungmalesn = 387

   The Association of Lung Clearance Index with COPD and FEV¹ Reduction in 'Men Born in 1914'

   COPD·Apr 28, 2017

More on Pulmonary obstruction

1. Lung clearance index is associated with FEV1 in humans (High LCI).

   “Reduction of FEV1 between 55 and 68 years of age and incidence of pulmonary obstruction was highest in those with high LCI.”

   HumansHigh LCIlungmalesn = 387

   The Association of Lung Clearance Index with COPD and FEV¹ Reduction in 'Men Born in 1914'

   COPD·Apr 28, 2017

More on FEV1

1. Lung clearance index predicts COPD events in humans (Adjusted HR 2.34 (95% CI 1.17-4.69), Q4 versus Q1; p for trend 0.006).

   “This relationship remained significant after adjustments for confounding factors, including smoking and FEV1 (HR, Q4 vs Q1: 2.34 (1.17-4.69); p value for trend: 0.006).”

   HumansHighest versus lowest LCI quartile; adjusted for confounding factors, including smoking and FEV144 yearsmalesn = 674

   The Association of Lung Clearance Index with COPD and FEV¹ Reduction in 'Men Born in 1914'

   COPD·Apr 28, 2017

More on COPD events