Log-transformed remnant cholesterol

1. Log-transformed remnant cholesterol improves insulin resistance risk reclassification and discrimination in humans (NRI 0.381 (95% CI 0.165–0.597); IDI 0.025 (95% CI 0.007–0.0439)).

   “Adding lnRC to the base model improved risk reclassification and discrimination”

   HumansPolyendocrine metabolic ovarian syndrome; addition to the base modelfemalesn = 617

   Age-specific association between remnant cholesterol and insulin resistance in women with polyendocrine metabolic ovarian syndrome

   Frontiers in endocrinology·30 Sep 2026

1. Log-transformed remnant cholesterol predicts insulin resistance discrimination in humans (AUC 0.654 versus 0.523; DeLong P = 0.024).

   “the area under the curve (AUC) of lnRC for IR discrimination was higher among women aged <30 years than among those aged ≥30 years”

   HumansPolyendocrine metabolic ovarian syndrome; exploratory age-stratified ROC analysisfemales

   Age-specific association between remnant cholesterol and insulin resistance in women with polyendocrine metabolic ovarian syndrome

   Frontiers in endocrinology·30 Sep 2026

1. Log-transformed remnant cholesterol is associated with insulin resistance in humans (Q4 vs. Q1: OR 3.11, 95% CI 1.57–6.14).

   “Higher lnRC levels were significantly associated with increased odds of IR (Q4 vs. Q1: odds ratio [OR] = 3.11, 95% confidence interval [CI]: 1.57-6.14, P = 0.001).”

   HumansPolyendocrine metabolic ovarian syndrome; highest versus lowest lnRC quartilefemalesn = 617

   Age-specific association between remnant cholesterol and insulin resistance in women with polyendocrine metabolic ovarian syndrome

   Frontiers in endocrinology·30 Sep 2026

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