LISP referral
Biomarker1 paper6 findings
One human cohort after acute heart failure hospitalisation links LISP referral to lower six-month survival, higher discharge NT-proBNP and major neurocognitive disorders, and lower daily-living scores and medication counts. SGLT2 inhibitor use is associated with lower referral odds when LVEF exceeds 50%.
- Humans1
Associations
66-month survival
downin humans1
1 study
6-month survival
downin humans1
LISP referral is associated with 6-month survival in humans (47.6% vs. 79.5% survival).
HumansDischarged after acute heart failure hospitalisation; LISP referral versus no referral6 months52% womensn = 604
Palliative-Oriented Referral and Advanced Vulnerability in Very Old Patients Hospitalised for Acute Heart Failure · ESC heart failure · 7 Oct 2026
Number of discharge medications
downin humans1OR 0.88
1 study
Number of discharge medications
downin humans1OR 0.88
number of discharge medications are associated with LISP referral in humans (OR 0.88, 95% CI 0.79–0.97).
HumansDischarged after acute heart failure hospitalisation; exploratory multivariable logistic regression52% womensn = 604
Palliative-Oriented Referral and Advanced Vulnerability in Very Old Patients Hospitalised for Acute Heart Failure · ESC heart failure · 7 Oct 2026
SGLT2 inhibitors
downin humans1OR 0.49
1 study
SGLT2 inhibitors
downin humans1OR 0.49
SGLT2 inhibitors are associated with LISP referral in humans (OR 0.49, 95% CI 0.27–0.88).
HumansDischarged after acute heart failure hospitalisation; LVEF >50%; exploratory multivariable logistic regression
Palliative-Oriented Referral and Advanced Vulnerability in Very Old Patients Hospitalised for Acute Heart Failure · ESC heart failure · 7 Oct 2026
NT-proBNP
upin humans1OR 1.35
1 study
NT-proBNP
upin humans1OR 1.35
NT-proBNP is associated with LISP referral in humans (OR 1.35, 95% CI 1.08–1.69).
HumansDischarged after acute heart failure hospitalisation; log-transformed discharge NT-proBNP in exploratory multivariable logistic regression52% womensn = 604
Palliative-Oriented Referral and Advanced Vulnerability in Very Old Patients Hospitalised for Acute Heart Failure · ESC heart failure · 7 Oct 2026
Major neurocognitive disorders
upin humans1OR 2.98
1 study
Major neurocognitive disorders
upin humans1OR 2.98
Major neurocognitive disorders are associated with LISP referral in humans (OR 2.98, 95% CI 1.73–5.13).
HumansDischarged after acute heart failure hospitalisation; exploratory multivariable logistic regression52% womensn = 604
Palliative-Oriented Referral and Advanced Vulnerability in Very Old Patients Hospitalised for Acute Heart Failure · ESC heart failure · 7 Oct 2026
Activities of Daily Living score
downin humans1OR 0.45
1 study
Activities of Daily Living score
downin humans1OR 0.45
Activities of Daily Living score is associated with LISP referral in humans (OR 0.45, 95% CI 0.37–0.55).
HumansDischarged after acute heart failure hospitalisation; exploratory multivariable logistic regression52% womensn = 604
Palliative-Oriented Referral and Advanced Vulnerability in Very Old Patients Hospitalised for Acute Heart Failure · ESC heart failure · 7 Oct 2026