LE8 DNAm score

1. LE8 DNAm score has no effect on carotid plaque in humans.

   “Associations with carotid plaque were not significant.”

   Humans

   Intergenerational and life-course links between a cardiovascular health-related methylation score and early vascular changes

   medRxiv·10 Aug 2026Preprint

More on Carotid plaque

1. LE8 DNAm score predicts carotid intima-media thickness in humans ({beta} = -0.030 mm/SD).

   “higher baseline DNAm score was associated with lower cIMT measured seven years later ({beta} = -0.030 mm/SD; p-value = 1.1 x 10-)”

   Humansseven years

   Intergenerational and life-course links between a cardiovascular health-related methylation score and early vascular changes

   medRxiv·10 Aug 2026Preprint

2. LE8 DNAm score is associated with carotid intima-media thickness in humans ({beta} = -0.022 mm/SD, p = 0.02).

   “Higher parental LE8 DNAm score was associated with lower offspring cIMT ({beta} = -0.022 mm/SD; p-value = 0.02)”

   Humans

   Intergenerational and life-course links between a cardiovascular health-related methylation score and early vascular changes

   medRxiv·10 Aug 2026Preprint

More on Carotid intima-media thickness