LDL genetic risk score

1. LDL genetic risk score increases low-density lipoprotein cholesterol in humans (P = 0.010 to P = 1.1 x 10(-16)).

   “Up to 90 years of age, in each age stratum individuals with high LDL GRS had higher LDL-C levels (P = 0.010 to P = 1.1 x 10(-16)).”

   Humans

   LDL cholesterol still a problem in old age? A Mendelian randomization study

   International journal of epidemiology·7 Apr 2015

More on Low-density lipoprotein cholesterol

1. LDL genetic risk score raises the risk of mortality in humans (13% increased risk, P-trend = 0.043).

   “In longitudinal analysis, high GRS was associated with increased all-cause mortality in individuals > 90 years, with a 13% increased risk in individuals with the highest LDL GRS (P-trend = 0.043).”

   Humans

   LDL cholesterol still a problem in old age? A Mendelian randomization study

   International journal of epidemiology·7 Apr 2015

1. LDL genetic risk score is associated with familial longevity in humans (β = 0.66 (SE = 0.23), P = 0.005).

   “individuals with a genetic predisposition for longevity had significantly lower LDL GRS compared with age-matched individuals of the general population”

   HumansLLS offspring vs partners

   LDL cholesterol still a problem in old age? A Mendelian randomization study

   International journal of epidemiology·7 Apr 2015

1. LDL genetic risk score is associated with chronological age in humans (β = -0.021 (SE = 0.01) per year, P = 0.018).

   “The frequency of LDL-increasing alleles decreased with increasing age [β = -0.021 (SE = 0.01) per year, P = 0.018].”

   Humans

   LDL cholesterol still a problem in old age? A Mendelian randomization study

   International journal of epidemiology·7 Apr 2015