L-HDL-C%

1. NfL is associated with L-HDL-C% in humans (Spearman ρ -0.39, 95% CI -0.59 to -0.15).

   “Serum neurofilament light chain was inversely correlated with L-HDL-C% levels at the same time point (Spearman ρ, -0.39; 95% CI, -0.59 to -0.15)”

   Humansat the start of CPB during cardiac surgeryserum

   Intraoperative Lipoproteins Associated with Postoperative Delirium in a Prospective Observational Study of Older Adults Undergoing Cardiac Surgery

   Journal of cardiothoracic and vascular anesthesia·Oct 1, 2025

More on NfL

1. L-HDL-C% lowers the risk of delirium in humans (OR 0.23, 95% CI 0.08-0.66).

   “Metabolomic analysis of serum revealed an association between the abundance of cholesterol in large high-density lipoprotein (L-HDL-C%) at the start of CPB and the development of postoperative delirium (odds ratio per standard deviation increment in biomarker concentration, 0.23; 95% confidence interval [CI], 0.08-0.66).”

   Humansat start of CPB during cardiac surgeryserumn = 57

   Intraoperative Lipoproteins Associated with Postoperative Delirium in a Prospective Observational Study of Older Adults Undergoing Cardiac Surgery

   Journal of cardiothoracic and vascular anesthesia·Oct 1, 2025

More on Delirium