Insulin secretion-sensitivity INDEX-2

Biomarker1 paper3 findings

Humans1

Associations

3

1-hour plasma glucose

downin humans1

1 study

Insulin secretion-sensitivity INDEX-2 is associated with 1-hour plasma glucose in humans (β -1.189 mmol/L, p < 0.001).
Humansper 1-SD increase in Chinese adults with prediabetes
OGTT-Derived β-Cell Function-Based Stratification of 2-Year Glycaemic Transitions in Chinese Adults With Prediabetes · Diabetes, obesity & metabolism · 13 Sep 2026

1-hour plasma glucose →

Normoglycemia

upin humans1OR 1.447

1 study

Insulin secretion-sensitivity INDEX-2 is associated with normoglycemia in humans (OR 1.447, 95% CI: 1.106-1.893).
Humansper 1-SD increase in Chinese adults with prediabetes
OGTT-Derived β-Cell Function-Based Stratification of 2-Year Glycaemic Transitions in Chinese Adults With Prediabetes · Diabetes, obesity & metabolism · 13 Sep 2026

Type 2 diabetes

downin humans1OR 0.505

1 study

Insulin secretion-sensitivity INDEX-2 lowers the risk of type 2 diabetes in humans (OR 0.505, 95% CI: 0.382-0.668).
Humansper 1-SD increase in Chinese adults with prediabetes
OGTT-Derived β-Cell Function-Based Stratification of 2-Year Glycaemic Transitions in Chinese Adults With Prediabetes · Diabetes, obesity & metabolism · 13 Sep 2026

Type 2 diabetes →

Latest

1

Diabetes, Obesity & MetabolismHumans14 Sep

OGTT-Derived β-Cell Function-Based Stratification of 2-Year Glycaemic Transitions in Chinese Adults With Prediabetes