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Immune entropy

There are 3 papers on immune entropy in aging research: 3 observational studies in people.

Biomarker

3 papers study it7 findings

See all 3

“immune entropy was inversely related to vaccine responsiveness regardless of age”
Pre-Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine ResponsivenessAging cell2025doi:10.1111/acel.70151
  • Humans3

Effects

1

Vaccine responsiveness

downin humans1

1 study

  1. Immune entropy is linked with lower vaccine responsiveness in humans.

    “immune entropy was inversely related to vaccine responsiveness regardless of age”

    Humans

    Pre-Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness

    Aging cell

Associations

6

Kidney transplantation

upin humans1

1 study

  1. Kidney transplantation is associated with immune entropy in kidney transplant recipients compared to healthy counterparts.

    “kidney transplant recipients, typically exhibiting diminished vaccine responses, demonstrated significantly increased immune entropy compared to healthy counterparts”

    Humansin kidney transplant recipients compared to healthy counterparts

    Pre-Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness

    Aging cell

More on Kidney transplantation

Antibody response

downin humans1

1 study

  1. Immune entropy is associated with antibody response in a validation cohort of older adults.

    “higher immune entropy was also associated with a lower antibody response to the BNT162b2 vaccine”

    Humansin a validation cohort of older adults

    Pre-Vaccination Immunotypes and Immune Entropy Are Indicators of Multiple Vaccine Responsiveness

    Aging cell

More on Antibody response

CD31+ naive T cells

upin humans1

1 study

  1. CD31+ naive T cells are associated with immune entropy in humans.

    “CD31 + naïve T cell subsets showed a stronger correlation with immune entropy, a measure of cumulative immune system perturbations, than with age itself.”

    Humans

    CD31 + naïve T cells associate with immunosenescence and responsiveness to multiple vaccines in older adults

    Immunity & ageing : I & A

More on CD31+ naive T cells

Kidney transplant recipient status

upin humans1

1 study

  1. kidney transplant recipient status is associated with immune entropy in humans (kidney transplant recipients versus healthy counterparts).

    “demonstrated significantly increased immune entropy compared to healthy counterparts”

    Humanskidney transplant recipients versus healthy counterparts

    Baseline immunotypes and immune entropy are indicators of multiple vaccine responsiveness

    medRxivPreprint

BNT162b2 vaccine antibody response

downin humans1

1 study

  1. Immune entropy is associated with BNT162b2 vaccine antibody response in humans (validation cohort of older adults).

    “higher immune entropy was also associated with a lower antibody response to the BNT162b2 vaccine”

    Humansvalidation cohort of older adults

    Baseline immunotypes and immune entropy are indicators of multiple vaccine responsiveness

    medRxivPreprint

More on BNT162b2 vaccine antibody response

Vaccine responsiveness

downin humans1

1 study

  1. Immune entropy is associated with vaccine responsiveness in humans (triple vaccination with influenza, pneumococcal, and SARS-CoV-2 vaccines).

    “immune entropy was inversely related to vaccine responsiveness regardless of age”

    Humanstriple vaccination with influenza, pneumococcal, and SARS-CoV-2 vaccines

    Baseline immunotypes and immune entropy are indicators of multiple vaccine responsiveness

    medRxivPreprint

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