What does the research say about HSC mutation detection?

HSC mutation detection

There is 1 paper on HSC mutation detection in aging research: 1 observational study in people. The newest story, Oct 29, 2026: “Stem-cell mutations predicted blood cancer relapse after transplant”.

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“HSC mutation detection preceded relapse by a mean of 98 days and strongly predicted relapse (95.7% vs. 30.3%; hazard ratio, 8.8; P=1.5e-7).”

Persistent Malignant Stem Cells Drive Relapse After Transplantation in the Myelodysplastic NeoplasmsbioRxiv2026doi:10.64898/2026.10.28.761431

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Post-transplant relapse

upin humans1HR 8.8

1 study

HSC mutation detection predicts post-transplant relapse in humans (myelodysplastic neoplasms after allogeneic transplantation) (95.7% vs. 30.3%; HR 8.8; detection preceded relapse by a mean of 98 days).
“HSC mutation detection preceded relapse by a mean of 98 days and strongly predicted relapse (95.7% vs. 30.3%; hazard ratio, 8.8; P=1.5e-7).”
Humansmyelodysplastic neoplasms after allogeneic transplantationhematopoietic stem cell
Stem-cell mutations predicted blood cancer relapse after transplant
bioRxivOct 29, 2026Preprint

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bioRxivOct 29

Stem-cell mutations predicted blood cancer relapse after transplant

Relapse was reported in 95.7% of patients with detected stem-cell mutations versus 30.3% without them in an observational cohort after transplantation.Relapse was reported in 95.7% of patients with detected stem-cell mutations versus 30.3% without them in an observational cohort after transplantation.

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HSC mutation detection

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Stem-cell mutations predicted blood cancer relapse after transplant

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