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High lipoprotein(a) combined with low prognostic nutritional index

Biomarker

2 findings

“high Lp(a) combined with low PNI was associated with the highest risk of all-cause mortality”
Lipoprotein(a) and Prognostic Nutritional Index Levels Exhibit Interactive and Joint Effects on Mortality Risk in Patients With Coronary Artery Disease: Findings From a Real-World StudyReviews in cardiovascular medicine2026doi:10.31083/rcm51948

Associations

2

Cardiovascular mortality

upin humans1HR 2.2

1 study

  1. High lipoprotein(a) combined with low prognostic nutritional index is associated with cardiovascular mortality in humans (Coronary artery disease; Lp(a) ≥30 mg/dL and PNI <45 versus Lp(a) <15 mg/dL and PNI ≥45) (HR 2.20, 95% CI 1.98–2.46).

    “and CV mortality (HR 2.20, 95% CI 1.98–2.46), compared with the low Lp(a)/high PNI reference group.”

    HumansCoronary artery disease; Lp(a) ≥30 mg/dL and PNI <45 versus Lp(a) <15 mg/dL and PNI ≥45Median follow-up of 5.2 yearsn = 47,482

    Lipoprotein(a) and Prognostic Nutritional Index Levels Exhibit Interactive and Joint Effects on Mortality Risk in Patients With Coronary Artery Disease: Findings From a Real-World Study

    Reviews in cardiovascular medicine

Mortality

upin humans1HR 1.85

1 study

  1. High lipoprotein(a) combined with low prognostic nutritional index is associated with mortality in humans (Coronary artery disease; Lp(a) ≥30 mg/dL and PNI <45 versus Lp(a) <15 mg/dL and PNI ≥45) (HR 1.85, 95% CI 1.69–2.03).

    “high Lp(a) combined with low PNI was associated with the highest risk of all-cause mortality”

    HumansCoronary artery disease; Lp(a) ≥30 mg/dL and PNI <45 versus Lp(a) <15 mg/dL and PNI ≥45Median follow-up of 5.2 yearsn = 47,482

    Lipoprotein(a) and Prognostic Nutritional Index Levels Exhibit Interactive and Joint Effects on Mortality Risk in Patients With Coronary Artery Disease: Findings From a Real-World Study

    Reviews in cardiovascular medicine