Neurobiology of Disease
Mice show altered brain rhythms before Alzheimer’s plaques form
Brain recordings in a mouse model of Alzheimer’s disease detected altered fast and slow rhythms at 1 month, without plaques or nerve-cell loss.Brain recordings in a mouse model of Alzheimer’s disease detected altered fast and slow rhythms at 1 month, without plaques or nerve-cell loss.
Mouse studyAlzheimer's disease
Who was studied5XFAD and wild-type mice, against wild-type mice
What changedAt 1 month, plaque-free model mice had less low-frequency and more high-frequency brain activity than control mice
The catchBrain recordings measured rhythm changes, not the signals’ accuracy for detecting early Alzheimer’s disease