HE4

1. HE4 raises the risk of chronic lower respiratory disease mortality in humans (HR 3.16, 95% CI 1.26-7.91).

   Humans199.3-monthsfemalesn = 2,200

   Serum human epididymis protein 4 and long-term mortality in U.S. women: a nationally representative cohort study · Clinics (Sao Paulo, Brazil) · 11 Sep 2026

1. HE4 is associated with lung disease in humans (OR 1.34, 95% CI 1.06-1.71).

   Humansfemalesn = 2,200

   Serum human epididymis protein 4 and long-term mortality in U.S. women: a nationally representative cohort study · Clinics (Sao Paulo, Brazil) · 11 Sep 2026

Lung disease →

1. HE4 is associated with chronic kidney disease in humans (OR 2.07, 95% CI 1.38-3.12).

   Humansfemalesn = 2,200

   Serum human epididymis protein 4 and long-term mortality in U.S. women: a nationally representative cohort study · Clinics (Sao Paulo, Brazil) · 11 Sep 2026

Chronic kidney disease →

1. HE4 raises the risk of cancer mortality in humans (HR 1.60, 95% CI 1.02-2.49).

   Humans199.3-monthsfemalesn = 2,200

   Serum human epididymis protein 4 and long-term mortality in U.S. women: a nationally representative cohort study · Clinics (Sao Paulo, Brazil) · 11 Sep 2026

1. HE4 raises the risk of mortality in humans (HR 1.29, 95% CI 1.03-1.63).

   Humans199.3-monthsfemalesn = 2,200

   Serum human epididymis protein 4 and long-term mortality in U.S. women: a nationally representative cohort study · Clinics (Sao Paulo, Brazil) · 11 Sep 2026