Alzheimer's & Dementia
Brain enzyme contributes to memory problems after surgery in mice
Experiments in mice aged 18–20 months implicated an enzyme in brain support cells in male-specific memory problems during the week after surgery.Experiments in mice aged 18–20 months implicated an enzyme in brain support cells in male-specific memory problems during the week after surgery.
Mouse studyMechanisms
Who was studiedMale and female C57BL/6J mice
What changedAstrocytic GCPII knockdown or pharmacological inhibition improved memory and rescued cognitive deficits in aged male mice after surgery
The catchTracer entry measured fluid influx rather than waste clearance