GC-rich maternal mRNA stability

Reproductive aging increases GC-rich maternal mRNA stability in silico.

“reproductive aging remodels codon-optimality-linked, translation-coupled mRNA decay, stabilizing a subset of GC-rich maternal mRNA”

In silicooocytefemales

Codon Composition in Human Oocytes Reveals Age-Associated Defects in mRNA Decay

International journal of molecular sciences·26 Sep 2025