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Extremely low HDL cholesterol

Biomarker

2 findings

“extremely low HDL-C was associated with higher atherosclerotic cardiovascular disease”
Genetic-Phenotypic Discordance Reveals Distinct Cardiovascular and Mortality Risk at HDL Cholesterol ExtremesCirculation. Genomic and precision medicine2026doi:10.1161/circgen.126.005840

Associations

2

Mortality

upin humans1HR 1.25

1 study

  1. Extremely low HDL cholesterol is associated with mortality in humans (HDL-C <1 mmol/L; across ancestries) (UKB: HR 1.25 (95% CI 1.20–1.30); AoU: HR 1.64 (95% CI 1.37–1.96)).

    “and mortality (UKB: HR, 1.25 [95% CI, 1.20–1.30]; AoU: HR, 1.64 [95% CI, 1.37–1.96]) across ancestries.”

    HumansHDL-C <1 mmol/L; across ancestries

    Genetics linked to risks at “good” cholesterol extremes

    Circulation. Genomic and precision medicine

Atherosclerotic cardiovascular disease

upin humans1HR 1.33

1 study

  1. Extremely low HDL cholesterol is associated with atherosclerotic cardiovascular disease in humans (HDL-C <1 mmol/L; across ancestries) (UKB: HR 1.33 (95% CI 1.27–1.39); AoU: HR 1.32 (95% CI 1.08–1.61)).

    “extremely low HDL-C was associated with higher atherosclerotic cardiovascular disease”

    HumansHDL-C <1 mmol/L; across ancestries

    Genetics linked to risks at “good” cholesterol extremes

    Circulation. Genomic and precision medicine

More on Atherosclerotic cardiovascular disease