Ever smoking polygenic index

Ever smoking polygenic index is linked with a higher risk of mortality in humans (per one standard deviation larger PGI) (HR 1.12, 95% CI 1.09-1.14).

“PGIs most strongly predictive of all-cause mortality were ever smoking (hazard ratio [HR]=1.12, 95% confidence interval [95% CI] 1.09; 1.14 per one standard deviation larger PGI)”

Humansper one standard deviation larger PGI

Heterogeneous associations of polygenic indices of 35 traits with mortality: a register-linked population-based follow-up study

eLife·Feb 11, 2026