Epigenetic age prediction error

Longevity-LLM v0.1 improves epigenetic age prediction error in silico (4.34-year MAE).

“After reinforcement fine-tuning, the model achieved a 4.34-year MAE in epigenetic age prediction, surpassing the Horvath multi-tissue clock.”

In silico

The End of Aging Clocks: Training Foundation Models to Reason in Aging and Longevity

bioRxiv (Cold Spring Harbor Laboratory)·30 Mar 2026Preprint