There is 1 paper on dried blood spot progranulin levels in aging research: 1 observational study in people.
1 paper studies it3 findings
“DBScapillary progranulin levels were able to identify GRN mutation carriers with high accuracy”
- Humans1
Upstream
1GRNMUTATION
downin humans1
1 study
GRNMUTATION
downin humans1
GRNMUTATION is linked with lower dried blood spot progranulin levels in humans (heterozygous pathogenic mutation carriers versus non-mutation carriers) (2.38 ng/mL (SD 1.0) vs 4.37 ng/mL (SD 0.68); U = 42; p < 0.0001).
“DBScapillary progranulin levels in GRN mutation carriers (mean [SD] age, 55 [13] years; n = 16) were reduced compared to non-mutation carriers”
Humansheterozygous pathogenic mutation carriers versus non-mutation carriersdried blood spots from capillary finger-stick collectionn = 44
Alzheimer's & dementia : the journal of the Alzheimer's Association
Associations
2Venous plasma progranulin levels
upin humans1
1 study
Venous plasma progranulin levels
upin humans1
Dried blood spot progranulin levels are associated with venous plasma progranulin levels in humans (R = 0.819; p < 0.001).
“highly associated with venous plasma levels (R = 0.819; p < 0.001)”
Humansdried blood spots from capillary finger-stick collection versus venous EDTA plasma
Alzheimer's & dementia : the journal of the Alzheimer's Association
GRN mutation carrier status
upin humans1
1 study
GRN mutation carrier status
upin humans1
Dried blood spot progranulin levels predict GRN mutation carrier status in humans (carriers versus non-carriers) (ROC AUC = 0.94 [95% CI: 0.83 to 1.00]).
“DBScapillary progranulin levels were able to identify GRN mutation carriers with high accuracy”
Humanscarriers versus non-carriersdried blood spots from capillary finger-stick collection
Alzheimer's & dementia : the journal of the Alzheimer's Association