What does the research say about DNA methylation at Polycomb-associated regulatory regions?

DNA methylation at Polycomb-associated regulatory regions

There is 1 paper on DNA methylation at Polycomb-associated regulatory regions in aging research: 1 observational study in people. The newest story, Nov 5, 2026: “Human blood retains DNA-marking patterns formed before birth”.

Biomarker

1 paper studies it2 findings

1 new paper in 30 daysSee all 1 papers on DNA methylation at Polycomb-associated regulatory regions

“Expansions do, however, converge on methylation change at Polycomb-associated regulatory regions, gaining methylation in most clades but losing it where DNMT3A is mutated.”

Evolution of the human methylome in blood from embryo to ageing and cancerResearch Square2026doi:10.21203/rs.3.rs-11370327/v1

Humans1

Associations

DNMT3A

downin humans1

1 study

DNMT3A is associated with DNA methylation at Polycomb-associated regulatory regions in humans (DNMT3A-mutated clonal expansions).
“Expansions do, however, converge on methylation change at Polycomb-associated regulatory regions, gaining methylation in most clades but losing it where DNMT3A is mutated.”
HumansDNMT3A-mutated clonal expansionsblood
Human blood retains DNA-marking patterns formed before birth
Research SquareNov 4, 2026Preprint

Latest

1 paper in 12 months

Research SquareNov 5

Human blood retains DNA-marking patterns formed before birth

Each blood cell carried about 300,000 acquired DNA-marking changes before birth, including more than 3,000 in large segments that remained stable for decades.Each blood cell carried about 300,000 acquired DNA-marking changes before birth, including more than 3,000 in large segments that remained stable for decades.

Preprint: cross-sectional · 13 peopleMechanisms

Paper

DNA methylation at Polycomb-associated regulatory regions

Associations

Latest

Human blood retains DNA-marking patterns formed before birth

Related