Disease burden and multisystem net accumulation

1 finding

“ranged from 1.9% to 24.6% across low-burden/low-accumulation and high-burden/high-accumulation phenotypes in acute care, and from 7.0% to 26.4% in chronic care.”

Multisystem disease accumulation in routine claims reveals dynamic multimorbidity and mortality risk in older adults: a multicentre retrospective cohort studyResearch Square2026doi:10.21203/rs.3.rs-11226533/v1

Associations

Mortality

upin humans1

1 study

Disease burden and multisystem net accumulation is associated with mortality in humans (Acute and chronic care) (Observed death: 1.9% versus 24.6% in acute care; 7.0% versus 26.4% in chronic care).
“ranged from 1.9% to 24.6% across low-burden/low-accumulation and high-burden/high-accumulation phenotypes in acute care, and from 7.0% to 26.4% in chronic care.”
HumansAcute and chronic care12 months after the 6-month landmarkn = 5,018
Rising diagnosis counts linked to death risk in older adults
Research SquareNov 5, 2026Preprint