CT-derived total lung volume

1. CT-derived total lung volume is associated with cardiometabolic disease in humans (Full lung cancer screening cohort; prevalent disease).

   “higher lung volume was associated with lower odds of cardiometabolic disease.”

   HumansFull lung cancer screening cohort; prevalent diseaselungn = 7,535

   Smaller lung volume linked to higher death risk in some smokers

   The Lancet medical imaging & theranostics·Nov 1, 2026

More on Cardiometabolic disease

1. CT-derived total lung volume predicts preserved ratio impaired spirometry in humans (Full lung cancer screening cohort) (AUROC 0.73).

   “Across the full cohort, lung volume discriminated PRISm with moderate accuracy (area under the receiver operating characteristic curve 0·73)”

   HumansFull lung cancer screening cohortlungn = 7,535

   Smaller lung volume linked to higher death risk in some smokers

   The Lancet medical imaging & theranostics·Nov 1, 2026

More on Preserved ratio impaired spirometry

1. CT-derived total lung volume is associated with mortality in humans (Participants with preserved ratio impaired spirometry) (Adjusted HR 0.71 per 1-SD increase, 95% CI 0.57–0.88; adjusted HR 0.76 after FVC adjustment).

   “each 1-SD increase in lung volume was associated with reduced hazard of death (adjusted HR 0·71, 95% CI 0·57–0·88; p=0·002)”

   HumansParticipants with preserved ratio impaired spirometrylungEach 1-SD increase in lung volumeMedian 5.0 yearsn = 1,355

   Smaller lung volume linked to higher death risk in some smokers

   The Lancet medical imaging & theranostics·Nov 1, 2026