Cortical iron

1. Cortical iron mediates fluid cognition in humans.

   “whereas depthwise iron mediated age-related differences in general fluid cognition.”

   Humansage-related differences in general fluid cognitioncerebral cortexn = 138

   Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging

   Neurobiology of aging·Jan 28, 2025

1. Age increases cortical iron in humans.

   “Increased age was related both to less segregated functional networks and to increased cortical iron, especially for superficial depths.”

   Humanscerebral cortexn = 138

   Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging

   Neurobiology of aging·Jan 28, 2025

1. Cortical iron predicts functional network segregation in humans.

   “higher mean parietal iron predicted lower network segregation for adults younger than 45 years of age.”

   Humansparietal cortexn = 138

   Depthwise cortical iron relates to functional connectivity and fluid cognition in healthy aging

   Neurobiology of aging·Jan 28, 2025

1. age is associated with cortical iron in P. troglodytes.

   “iron accumulation continued throughout the lifespan.”

   Animalsneocortex

   Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology

   bioRxiv (Cold Spring Harbor Laboratory)·Dec 8, 2024Preprint

1. Pan troglodytes are associated with cortical iron in P. troglodytes.

   “Compared to humans, chimpanzees showed more myelination and iron deposition in motor and premotor cortices”

   AnimalsCompared with humansmotor and premotor cortex

   Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology

   bioRxiv (Cold Spring Harbor Laboratory)·Dec 8, 2024Preprint

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