Coronary total plaque volume

1. Statins have no effect on coronary total plaque volume in humans (P-interaction=0.25).

   “Baseline statin use did not modify the relationship between relugolix versus no ADT and ΔTPV (P-interaction=0.25).”

   Human trialin relugolix versus no ADTcoronary artery12 monthsmales

   Statin Use Mitigates Androgen Deprivation Therapy-Associated Coronary Atherosclerosis in Prostate Cancer: A Secondary Analysis of the REVELUTION Randomized Clinical Trial

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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1. Leuprolide increases coronary total plaque volume in humans (+117.9 mm3, 95% CI 53.3-182.4, P<0.001).

   “When compared to the no ADT arm, leuprolide treatment in statin non-users was associated with significantly increased mean-adjusted 1-year ΔTPV (+117.9 mm 3 , 95% CI 53.3-182.4, P<0.001)”

   Human trialin statin non-users compared to no ADTcoronary artery12 monthsmales

   Statin Use Mitigates Androgen Deprivation Therapy-Associated Coronary Atherosclerosis in Prostate Cancer: A Secondary Analysis of the REVELUTION Randomized Clinical Trial

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

More on Leuprolide