Coronary heart disease polygenic risk score

1. Coronary heart disease polygenic risk score improves coronary heart disease risk prediction discrimination in humans (C-statistic from 0.719 to 0.753 (P-diff=9.1×10−3)).

   “incorporating PRS CHD and FamHx into PCE improved discrimination (C-statistic increased from 0.719 to 0.753; P -diff=9.1×10 −3”

   Humansincorporating PRS CHD and FamHx into PCE

   Incorporation of Genetic Risk Factors for Coronary Heart Disease into Clinical Risk Calculators Improved Risk Prediction in Three Major Race/Ethnicity Groups in the United States

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

1. Coronary heart disease polygenic risk score is associated with coronary heart disease in humans.

   “PRS CHD and FamHx were independently and additively associated with CHD in two large diverse cohorts in the US.”

   Humansindependent and additive effects

   Incorporation of Genetic Risk Factors for Coronary Heart Disease into Clinical Risk Calculators Improved Risk Prediction in Three Major Race/Ethnicity Groups in the United States

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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