Composite immune index

age decreases composite immune index in humans (from -2.64 units/year to -10.66 units/year).

“The CII, integrating 11 immune parameters, exhibited a significant inflection point at age 63 (p < 0.001), with the rate of decline accelerating from − 2.64 units/year to − 10.66 units/year thereafter”

Humans

Age-associated changes in major lymphocyte subsets and sex-specific patterns in healthy Chinese adults

Scientific reports·8 Apr 2026