What does the research say about ClinicalAge?

ClinicalAge

There is 1 paper on ClinicalAge in aging research: 1 observational study in people. The newest story, Nov 12, 2026: “Health-record aging measure linked to disease and death”.

Biomarker

1 paper studies it6 findings

1 new paper in 30 daysSee all 1 papers on ClinicalAge

“showed a significant association with the 17 functional measures and ten biological ageing biomarkers.”

ClinicalAge, a framework for modelling ageing trajectories from longitudinal electronic health records in the UK: a model development and validation studyThe Lancet. Digital health2026doi:10.1016/j.landig.2026.101060

Humans1

Associations

Cardiovascular mortality

upin humans1HR 1.33

1 study

ClinicalAge is associated with cardiovascular mortality in humans (Adjusted for clinical covariates and lifestyle factors) (UK Biobank adjusted HR 1.33 (95% CI 1.29–1.36); CPRD adjusted HR 1.36 (1.35–1.36)).
“cardiovascular mortality (UK Biobank adjusted HR 1·33 [1·29–1·36]; CPRD adjusted HR 1·36 [1·35–1·36])”
HumansAdjusted for clinical covariates and lifestyle factors
Health-record aging measure linked to disease and death
The Lancet. Digital healthNov 1, 2026

Cancer mortality

upin humans1HR 1.12

1 study

ClinicalAge is associated with cancer mortality in humans (Adjusted for clinical covariates and lifestyle factors) (UK Biobank adjusted HR 1.12 (95% CI 1.10–1.14); CPRD adjusted HR 1.17 (1.16–1.17)).
“cancer mortality (UK Biobank adjusted HR 1·12 [1·10–1·14]; CPRD adjusted HR 1·17 [1·16–1·17])”
HumansAdjusted for clinical covariates and lifestyle factors
Health-record aging measure linked to disease and death
The Lancet. Digital healthNov 1, 2026

Mortality

upin humans1HR 1.23

1 study

ClinicalAge is associated with mortality in humans (Adjusted for clinical covariates and lifestyle factors) (UK Biobank adjusted HR 1.23 (95% CI 1.21–1.24); CPRD adjusted HR 1.36 (1.36–1.36)).
“ClinicalAge was significantly associated with all-cause mortality”
HumansAdjusted for clinical covariates and lifestyle factors
Health-record aging measure linked to disease and death
The Lancet. Digital healthNov 1, 2026

Aging-related disease incidence

mixedin humans1

1 study

ClinicalAge is associated with aging-related disease incidence in humans (UK Biobank and CPRD Aurum) (All 20 non-cancer diseases; 9/11 cancers in UK Biobank and 10/11 in CPRD, with positive and negative cancer associations).
“It was also significantly associated with the incidence of all 20 non-cancer diseases in both datasets”
HumansUK Biobank and CPRD Aurum
Health-record aging measure linked to disease and death
The Lancet. Digital healthNov 1, 2026

Biological aging biomarkers

mixedin humans1

1 study

ClinicalAge is associated with biological aging biomarkers in humans (Significant associations with ten biological aging biomarkers).
“showed a significant association with the 17 functional measures and ten biological ageing biomarkers.”
Humans
Health-record aging measure linked to disease and death
The Lancet. Digital healthNov 1, 2026

Latest

1 paper in 12 months

The Lancet Digital HealthNov 12

Health-record aging measure linked to disease and death

An aging measure developed in 320,891 UK Biobank participants was linked to all 20 non-cancer diseases assessed in two UK datasets.An aging measure developed in 320,891 UK Biobank participants was linked to all 20 non-cancer diseases assessed in two UK datasets.

Cohort · 4,728,376 peopleBiomarkers

Paper

ClinicalAge

Associations

Latest

Health-record aging measure linked to disease and death

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