Aging Cell
Brain estrogen loss linked to memory problems in old female mice
Experiments in mice aged 6 to 8 months and over 19 months linked low brain estrogen to memory difficulties and altered gene activity in older females.Experiments in mice aged 6 to 8 months and over 19 months linked low brain estrogen to memory difficulties and altered gene activity in older females.
Mouse studyMechanisms
Who was studiedMale and female mice, against controls
What changedSpatial working memory was impaired in older female aromatase knockout mice compared to controls
The catchGene-activity analysis used three mice per group