Cell composition-adjusted buccal epigenetic age predictor

Cell composition-adjusted buccal epigenetic age predictor predicts chronological age in humans (MADs 5.09 and 5.12 years in two independent validation sets).

“Combination of cell type-specific and age-associated CpGs into one multivariate model enabled age predictions with MADs of 5.09 years and 5.12 years in two independent validation sets.”

Humanscombined cell type-specific and age-associated CpG model; two independent validation setsbuccal swab

Epigenetic age predictions based on buccal swabs are more precise in combination with cell type-specific DNA methylation signatures

Aging·May 1, 2016