CD4+ T cell TCR repertoire diversity

Healthy aging is associated with CD4+ T cell TCR repertoire diversity in humans.

“A significantly higher TCR repertoire diversity in the CD4+ T cells differentiated the healthy elderly individuals from the frailty ones.”

Humanshealthy versus age-matched frail individualsCD4+ T celln = 16

The T cell receptor repertoire captures healthy aging and CMV independently from epigenetic clocks

bioRxiv (Cold Spring Harbor Laboratory)·22 Feb 2026Preprint