CD28- naive CD8+ T cells

CD28- naive CD8+ T cells predict frailty in humans (OR = 1.649, p = 0.003).

“the percentage of CD28− TN (OR = 1.649, p = 0.003), age (OR = 1.222, p < 0.001), and number of comorbidities (OR = 1.334, p = 0.003) independently predicted frailty severity.”

Humansadjusted analysis

Peripheral CD8⁺ T cell subsets and physical frailty in community-dwelling older Thai adults: the role of age and multimorbidity

BMC geriatrics·14 Apr 2026