CARDIO inCode-Score

1. CARDIO inCode-Score increases net reclassification improvement in humans (10.7 (7.6-13.9)).

   “The category based Net Reclassification Improvement was 10.7 (7.6-13.9) in borderline/intermediate PREVENT risk.”

   Humansin borderline/intermediate PREVENT risk14 yearsn = 60,544

   Enhancing the PREVENT Equation with a Polygenic Risk Score: Clinical Utility Evaluation

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

1. CARDIO inCode-Score increases Harrell's C-index in humans (0.747 to 0.757, p<0.0001).

   “adding PRS to model containing PREVENT increased Harrell’s C statistic by 0.01 (0.747 to 0.757; p<0.0001).”

   Humansadjusting for 10 principal components of genetic ancestry14 yearsn = 60,544

   Enhancing the PREVENT Equation with a Polygenic Risk Score: Clinical Utility Evaluation

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

1. CARDIO inCode-Score predicts coronary heart disease in humans.

   “individuals with borderline PREVENT/high PRS had significantly higher rate than intermediate PREVENT/low PRS”

   Humans14 yearsn = 60,544

   Enhancing the PREVENT Equation with a Polygenic Risk Score: Clinical Utility Evaluation

   AHA Scientific Sessions 2025 abstract·3 Nov 2025

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