CalibratedTotalRisk
Biomarker1 paper2 findings
- Humans1
Effects
1Mortality discrimination
no changein humans1upin humans1
1 study
Mortality discrimination
no changein humans1upin humans1
CalibratedTotalRisk has no effect on mortality discrimination in humans (C-index difference 0.002, paired 95% CI −0.003 to 0.007).
HumansCompared with PhenoAge NCP, a no-CRP proxy, in internal temporal validationn = 6,739
Separating age and physiology can preserve death-risk ranking · Research Square · 6 Oct 2026 · Preprint
CalibratedTotalRisk improves mortality discrimination in humans (C-index difference 0.016, paired 95% CI 0.011–0.022).
HumansCompared with DemoRisk in internal temporal validationn = 6,739
Separating age and physiology can preserve death-risk ranking · Research Square · 6 Oct 2026 · Preprint
Latest
1Separating age and physiology can preserve death-risk ranking
The combined score reached 0.843 on a measure of death-risk ranking, exceeding the age-and-sex score by 0.016 in 6,739 validation participants.The combined score reached 0.843 on a measure of death-risk ranking, exceeding the age-and-sex score by 0.016 in 6,739 validation participants.