Brain MRI peak differentiation

Age decreases brain MRI peak differentiation in humans (beta = -0.012, 95% CI [-0.0132, -0.0105], p < 0.001).

“Reduced whole-brain peak differentiation was associated with older age ([Formula: see text] = - 0.012, 95% CI [-0.0132, -0.0105], p < 0.001)”

Humanshealthy participantsbrainn = 178

Automated characterization of the gray matter white matter distribution demonstrates age-related decline

Scientific reports·13 Jan 2026