Brain-health score
Biomarker2 papers5 findings
In a human cohort, higher brain-health scores are associated with slower executive, memory and language decline. A human cohort preprint links higher scores to lower incident self-reported stroke risk, with stroke discrimination of AUC 0.645.
- Humans2
Effects
3Language decline
downin humans1
1 study
Language decline
downin humans1
Brain-health score decreases language decline in humans (0.011 SD/year slower language decline).
Humans14.3 yearsn = 639
Sleep electroencephalography-derived brain health and long-term cognitive decline in community-dwelling adults · Sleep advances : a journal of the Sleep Research Society · 6 Aug 2026
Executive function decline
downin humans1
1 study
Executive function decline
downin humans1
Brain-health score decreases executive function decline in humans (0.009 SD/year slower executive function decline).
Humans14.3 yearsn = 639
Sleep electroencephalography-derived brain health and long-term cognitive decline in community-dwelling adults · Sleep advances : a journal of the Sleep Research Society · 6 Aug 2026
Memory decline
downin humans1
1 study
Memory decline
downin humans1
Brain-health score decreases memory decline in humans (0.015 SD/year slower memory decline).
Humans14.3 yearsn = 639
Sleep electroencephalography-derived brain health and long-term cognitive decline in community-dwelling adults · Sleep advances : a journal of the Sleep Research Society · 6 Aug 2026
Associations
2Stroke
mixedin humans1
1 study
Stroke
mixedin humans1
Brain-health score predicts stroke in humans (AUC 0.645).
HumansCHARLS model-development dataset; discrimination performance
Modifiable health-factor burden and stroke outcomes across three population databases: cross-sectional and longitudinal evidence from NHANES, CHARLS and HRS · Research Square · 5 Oct 2026 · Preprint
Incident self-reported stroke
downin humans1HR 0.74
1 study
Incident self-reported stroke
downin humans1HR 0.74
Brain-health score is associated with incident self-reported stroke in humans (HR 0.740, 95% CI 0.712–0.769 per 1-point higher score).
HumansCHARLS longitudinal analysis; per 1-point higher score2011–2018
Modifiable health-factor burden and stroke outcomes across three population databases: cross-sectional and longitudinal evidence from NHANES, CHARLS and HRS · Research Square · 5 Oct 2026 · Preprint